Indole alkaloids with potential anticancer activity

D Xu, Z Xu - Current topics in medicinal chemistry, 2020 - ingentaconnect.com
… occupy an important position in the discovery of novel anticancer agents. … of indole alkaloids
as potential anticancer agents, their structure-activity relationship, and mechanisms of action

Indole alkaloids, synthetic dimers and hybrids with potential in vivo anticancer activity

F Song, Y Bian, J Liu, Z Li, L Zhao… - Current Topics in …, 2021 - ingentaconnect.com
… of indole alkaloids, synthetic dimers and hybrids with potential in vivo anticancer activity, …
Moreover, the mechanisms of action, as well as the structure-activity relationships (SARs), …

A novel monoterpenoid indole alkaloid with anticancer activity from Melodinus khasianus

J Zhou, JH Feng, L Fang - Bioorganic & medicinal chemistry letters, 2017 - Elsevier
… In conclusion, we reported a novel monoterpenoid indole alkaloid, khasuanine A with
unprecedented 6/5/6/4/6 fused rings, isolated from the roots of M. khasianus. Khasuanine A …

Anticancer activity of bisindole alkaloids derived from natural sources and synthetic bisindole hybrids

Y Zhang, C Hu - Archiv der Pharmazie, 2020 - Wiley Online Library
alkaloids derived from nature and of synthetic hybrids with potential anticancer activity
The monoterpenoid indole alkaloid 30 (IC 50 : 10.25–12.55 μM; MTT assay), isolated from …

The current scenario of naturally occurring indole alkaloids with anticancer potential

J Song, B Zhang, M Li, J Zhang - Fitoterapia, 2023 - Elsevier
… to provide more lead hits or candidates; (2) further evaluation of the current available
indole alkaloids with high anticancer activity to seek for more promising preclinical/clinical …

[HTML][HTML] Advances in indole-containing alkaloids as potential anticancer agents by regulating autophagy

ML Luo, W Huang, HP Zhu, C Peng, Q Zhao… - Biomedicine & …, 2022 - Elsevier
indole alkaloids' effect on tumor cells and autophagy. Then, we focus on mechanisms by which
indole alkaloids … The antitumor activity of indole alkaloids has been extensively studied in …

A novel bis-indole destabilizes microtubules and displays potent in vitro and in vivo antitumor activity in prostate cancer

S Ahn, DJ Hwang, CM Barrett, J Yang, CB Duke… - Cancer chemotherapy …, 2011 - Springer
… a series of novel indoles that exhibit potent anticancer activities. These indoles were synthesized
by … Clinical use of indole alkaloids is currently restricted to vinblastine, vincristine and …

Bis-indole alkaloid caulerpin from a new source Sargassum platycarpum: isolation, characterization, in vitro anticancer activity, binding with nucleobases by DFT …

DA Abdelrheem, HR Abd El-Mageed… - Journal of …, 2021 - Taylor & Francis
… Caulerpin, a bis-indole alkaloid is isolated from a new source Sargassum platycarpum, …
In vitro anticancer activity of caulerpin has been explored by cell viability assay against new …

Natural indole‐containing alkaloids and their antibacterial activities

Y Liu, Y Cui, L Lu, Y Gong, W Han… - Archiv der …, 2020 - Wiley Online Library
activity of alkaloid 1 was inferior to that of chloramphenicol (inhibition zone: 32–40 mm at 15
µg/disc). Indole alkaloid … , not only showed the same level of anticancer activity (IC 50 : 40.1–…

Anticancer indole alkaloids of Ervatamia heyneana

SP Gunasekera, G Cordell, NR Farnsworth - Phytochemistry, 1980 - Elsevier
… and the latter genus has yielded several types of indole alkaloids ([l-lo]; Bruneton, J. et al., …
anticancer activity of the wood and E. dichotoma (Roxb.) Burk) did show anticancer activ- …